How to Survive Aneuploidy

How to Survive Aneuploidy

Aneuploidy, or an abnormal number of chromosomes, adversely affects cell growth, but it is also linked with cancer and tumorigenesis. Now, Torres et al. (2010) help to resolve this paradox by demonstrating that aneuploid yeast cells can evolve mutations in the proteasome protein degradation pathway that alleviate imbalances in protein production and increase the cell's proliferative capacities.

Cell populations can use aneuploidy to survive telomerase insufficiency

Telomerase maintains ends of eukaryotic chromosomes, telomeres. Telomerase loss results in replicative senescence and a switch to recombination-dependent telomere maintenance. Telomerase insufficiency in humans leads to telomere syndromes associated with premature ageing and cancer predisposition. Here we use yeast to show that the survival of telomerase insufficiency differs from the survival ...

How to Survive in Hospital

Dy f\ainarine vvnitenorn Eyre Methuen, 85p As a little something to take along to a hospital patient, this book has a great deal going for it. The pictures (by Bill Tidy), while lacking the great Giles' special brand of malicious hospital humour, are funny and reasonably apposite. The text is informative and lighthearted enough without being arch or gigglegiggle (a rare enough achievement in hu...

How to survive a nerve-wracking journey

When the axons that carry signals to muscles are growing, they rely on help from Frizzled3-a protein that is known to perform a number of other important functions in cells-to reach their final destination.

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